Nature

Activation of a tissue-specific stress response in the aqueous outflow pathway of the eye defines the glaucoma disease phenotype

The glaucomas are a group of optic neuropathies comprising the leading cause of irreversible blindness worldwide. Elevated intraocular pressure due to a reduction in normal aqueous outflow is a major ...
Nature

Direct, convergent hypersensitivity of calcium-activated force generation produced by hypertrophic cardiomyopathy mutant α-tropomyosins in adult cardiac myocytes

Figure 1: HCM mutant αTm structure and expression. The direct increase myofilament calcium sensitivity associated with HCM mutations in α-Tm reported here is in contrast to effects seen with HCM ...