Two new options for making designer proteins made news in 2001—both from labs at Scripps Research Institute. Since 2001, Schimmel and Schultz have taken different directions with unnatural amino acids ...

Evolutionary biochemistry aims to dissect the evolutionary processes and physical mechanisms by which biological molecules diversified and to reveal how their physical architecture facilitates and ...

Metabolic, signaling and regulatory pathways form the basis of biological processes and are important for the analysis of cellular behavior and evolution. This paper presents an approach of aligning ...

We introduce a method of looking at, analyzing, and comparing protein structures. The topology of a protein is captured by 30 numbers inspired by Vassiliev knot invariants. To illustrate the ...

Neurodegenerative diseases like Alzheimer's disease or Parkinson's disease are caused by folding errors (misfolding) in proteins or peptides, i.e. by changes in their spatial structure. This is the ...

A high-speed method has been developed to generate many different, small, stable proteins from scratch, custom-designed to bind to specific therapeutic targets. Protection against infectious diseases, ...

Amyloids are perhaps best known as a key driver of Alzheimer’s disease. The amorphous proteins, found throughout the human body, stick to nerve cells like plaque, choking off their function and ...