Thrombocytopenia, inherited as a dominant trait, was present in three generations of a kindred. The clinical picture was quite similar to that of idiopathic thrombocytopenic purpura, but ...

IMPAIRMENT of the hemostatic mechanism is a common experience in active disease of the liver. Several recent reports 1–4 have stressed the multiplicity of plasma clotting factors that may be deficient ...

Ado-trastuzumab emtansine (T-DM1) treatment results in grade 3-4 thrombocytopenia in 8%-13% of patients. Prior in vitro studies reported T-DM1 inhibition of megakaryocyte maturation as the cause of ...

HPS is an uncommon congenital bleeding disorder due to an underlying platelet function defect. As a result of intracytoplasmic organelle-specific protein biosynthesis and trafficking, HPS is a ...

Megakaryocytes, which are derived from hematopoietic stem cell precursors in bone marrow, form and release platelets; these circulate in the blood for 8 to 10 days before they are removed by hepatic ...

"Gut microbes influence platelet function, risk of thrombosis, study shows." ScienceDaily. www.sciencedaily.com / releases / 2016 / 03 / 160310125332.htm (accessed December 18, 2025).

The coronavirus disease-19 (COVID-19) pandemic that emerged in Wuhan, China, in late December 2019 spread rapidly throughout the world and has caused over 6.5 million deaths. The disease is caused by ...

Researchers from Miguel Hernández University of Elche (UMH) in Spain have identified an effective strategy to reduce structural liver damage and improve hepatic vascular function in cirrhosis.

The ZENITH trial showed sotatercept significantly reduced death, transplant, or hospitalization risk in advanced PAH, leading ...

The British Society for Haematology has released a new updated guideline that offers practical guidance for the management of specific situations and complications of polycythemia vera and outlines ...